Alzheimer’s Disease Neuroimaging Initiative’s Depression Project (ADNI-D)


This study's aim is to see what parts of the brain are responsible for cognitive function in adults ages 65 and older who are also currently experiencing symptoms of depression.

Study design

This is a longitudinal study, examining participants before and after a 2½-year period. That only includes four total appointments—two at the beginning and two at the end of the study period. At the beginning of the study period, volunteers come to the Parnassus location to go through symptoms of depression and cognitive testing. From there, volunteers will then be asked to go to the Mission Bay location to receive an MRI, a PET scan, have their blood drawn, and receive a physical. They will then wait 2½ years and then come back in to both locations to receive all of the same procedures.

Study coordinators will be reaching out to the participants at the 12- and 24-month period for a brief telephone check-in and mail the volunteer some self-report forms for them to fill out and then return.

Participant requirements

The ADNI-D Study is no longer recruiting new participants. 

  • 65+ years old
  • Currently experiencing symptoms of depression
  • Ability to go through an MRI and PET scan
  • Ability to have their blood drawn
  • No significant neurological diseases (Parkinson's disease, epilepsy, cortical stroke, traumatic brain injury)
  • No recent history of substance abuse or alcohol dependence


Volunteers can receive up to $300 for completing all sessions.

End date

May 20, 2020

Principal investigators

Contact information

You may contact the study coordinator by sending an email to [email protected] or by calling (415) 476-7046. You may also visit the study's webpage at for more information.