Alzheimer’s Disease Neuroimaging Initiative’s Depression Project (ADNI-D)

 

This study's aim is to see what parts of the brain are responsible for cognitive function in adults ages 65 and older who are also currently experiencing symptoms of depression.

Study design

This is a renewal study of a previously approved NIMH-funded study. This multi-site, longitudinal study will evaluate the mechanisms contributing to cognitive impairment and accelerated cognitive decline in Late Life Depression, examining our participants from our previously funded study before and after a 2½-year period. For this renewal study the study population will consist of 100 participants.  Enrolled participants will have four total appointments—two at the beginning and two at the end of the study period. At the beginning of the study period, participants come to the Mission Bay location to go through symptoms of depression and cognitive testing. From there, participants will then be asked to go to the San Francisco Veterans Affairs Medical Center location to receive an MRI, and two PET scans. They will then wait 2½ years and then come back to the Mission Bay location to receive all of the depression and cognitive testing.

Study coordinators will be reaching out to the participants at the 12- and 24-month period for a brief telephone check-in and will mail the volunteer some self-report forms for them to fill out and then return.

Participant requirements

The ADNI-D Study is no longer recruiting new participants. 

  • 65+ years old
  • Currently experiencing symptoms of depression
  • Ability to go through an MRI and PET scan
  • Ability to have their blood drawn
  • No significant neurological diseases (Parkinson's disease, epilepsy, cortical stroke, traumatic brain injury)
  • No recent history of substance abuse or alcohol dependence
     

Compensation

Volunteers can receive up to $520 for completing all sessions.

End date

May 31, 2027

Principal investigators

Contact information

You may contact the study coordinator by sending an email to [email protected] or calling 415-300-0582. You may also visit the study's webpage at latelifedepression.ucsf.edu for more information.