Research

Research (2015-present)

    1. Rhodes, E., Insel, P. S., Kassel, M., Kryza-Lacombe, M., Butters, M. A., Bickford, D., Tosun, D., Morin, R., Aisen, P., Rosen, H., Raman, R., Landau, S., Saykin, A., Toga, A. W., Jack, C. R., Weiner, M. W., Nelson, C., & Mackin, R. S. (2026). Response to "Brain Amyloid and Cognitive Decline in Late-Life Depression". The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 34(2), 258–261. https://doi.org/10.1016/j.jagp.2025.10.010 

    1. Rhodes, E., Insel, P. S., Kassel, M., Kryza-Lacombe, M., Butters, M. A., Bickford, D., Tosun, D., Morin, R., Aisen, P., Rosen, H., Raman, R., Landau, S., Saykin, A., Toga, A. W., Jack, C. R., Weiner, M. W., Nelson, C., & Mackin, R. S. (2026). Accelerated cognitive decline in late life depression: The role of amyloid-β, cortico-limbic volume, and white matter hyperintensities. American Journal of Geriatric Psychiatry. 

    1. Manning, K., Mackin, R., Wu, R., Nowrangi, M., Steffens, D., Boyle, P. (2025). The Independent Effect of Depression on Financial Decision-Making in Older Adults. The American Journal of Geriatric Psychiatry. 

    1. Fortel, I., Burns, A., Zhan, L., Ajilore, O., Mackin, R., Leow, A. (2025). Hyperexcitability Across Brain Networks in Late-Life Depression. AI in Neuroscience. 

    1. Coulborn, S., et al. (2025). Combining plasma neurofilament light chain and frontotemporal atrophy improves differentiation of bvFTD from primary psychiatric disorders. Alzheimer's & Dementia. 

    1. Kryza-Lacombe, M., Kassel, M., Insel, P., Nelson, J., Tosun, D., Mackin, R. (2025). 111. Gray Matter Volume Predicts Improvement in Depression Symptoms Following Problem Solving Therapy in Late Life Depression. The American Journal of Geriatric Psychiatry. 

    1. Aaronson, A., Diaz, A., Ashford, M. T., Jin, C., Tank, R., Miller, M. J., Kang, J. M., Manjavong, M., Landavazo, B., Eichenbaum, J., Truran, D., Camacho, M. R., Fockler, J., Flenniken, D., Vannini, P., Tomaszewski Farias, S., Mackin, R. S., Weiner, M. W., & Nosheny, R. L. (2025). Self- and informant-report cognitive decline discordance and mild cognitive impairment diagnosis. JAMA Network Open. 

    1. Ashford, M. T., Aaronson, A., Zhu, D., Deng, X., Kannan, S., Conti, C., Alaniz, R., Sorce, J., Cypress, C., Flenniken, D., Camacho, M., Fockler, J., Truran, D., Mackin, R. S., Hill, C., Weiner, M. W., Byrd, D., Turner, R. W., Cham, H., Rivera Mindt, M., & Nosheny, R. L. (2025). Community-engaged efforts to increase retention of Black American online registry participants. Alzheimer’s & Dementia: Translational Research & Clinical Interventions. 

    1. Ashford, M. T., Aaronson, A., Jin, C., Camacho, M. R., Eichenbaum, J., Ulbricht, A., Alaniz, R., Sorce, J., Kannan, S., Guerrero, L., Marquez, D. X., Flenniken, D., Fockler, J., Truran, D., Mackin, R. S., Mindt, M. R., Paredes, A. M., González, H. M., Weiner, M. W., & Nosheny, R. L. (2025). Digital efforts in Spanish for enrolling Latino adults in the Brain Health Registry. Alzheimer's & dementia (New York, N. Y.), 11(4), e70096. https://doi.org/10.1002/trc2.70096 

    1. Burns, A. P., Fortel, I., Zhan, L., Lazarov, O., Mackin, R. S., Demos, A. P., Bendlin, B., & Leow, A. (2025). Longitudinal excitation-inhibition balance altered by sex and APOE-ε4. Communications biology, 8(1), 488. https://doi.org/10.1038/s42003-025-07876-5 

    1. Kang, J. M., Manjavong, M., Jin, C., Diaz, A., Ashford, M. T., Eichenbaum, J., Thorp, E., Wragg, E., Zavitz, K. H., Cormack, F., Aaronson, A., Mackin, R. S., Tank, R., Landavazo, B., Cavallone, E., Truran, D., Farias, S. T., Weiner, M. W., & Nosheny, R. L. (2025). Subjective cognitive decline predicts longitudinal neuropsychological test performance in an unsupervised online setting in the Brain Health Registry. Alzheimer's research & therapy, 17(1), 10. https://doi.org/10.1186/s13195-024-01641-2 

    1. Kang, J. M., Manjavong, M., Diaz, A., Ashford, M. T., Aaronson, A., Eichenbaum, J., Mackin, S., Tank, R., Miller, M. J., Landavazo, B., Cavallone, E., Truran, D., Camacho, M. R., Fockler, J., Flenniken, D., Farias, S. T., Weiner, M. W., & Nosheny, R. (2025). Evaluating the Accuracy of Web-Based and In-Clinic Subjective Cognitive Decline Assessments in Detecting Cognitive Impairment: Multicohort Study. Journal of medical Internet research, 27, e69689. https://doi.org/10.2196/69689 

    1. Kryza-Lacombe, M., Abram, S. V., Potenza, M. N., Mackin, R. S., Lau, K. J., Nicholas, S. C., Ford, J. M., Batki, S. L., Mathalon, D. H., & Fryer, S. L. (2025). Larger neural responses to reward in gambling disorder: Relationships with depression and gambling severity. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 

    1. Mackin, R. S., Burns, E., Insel, P., Ganesh, N., Kassel, M., Kryza-Lacombe, M., Ashford, M., Eichenbaum, J., Miller, M., Aaronson, A., Tank, R., Camacho, M. R., Fockler, J., Truran, D., Ng, N. F., Nosheny, R., & Weiner, M. W. (2025). Test taking location and practice effects as factors contributing to scores on remotely administered neurocognitive performance tests in a sample of older adults. Applied Neuropsychology: Adult. 

    1. Nutley, S. K., Striley, C. W., Cottler, L. B., Eichenbaum, J., Nosheny, R. L., Mackin, R. S., & Mathews, C. A. (2025). Classification of hoarding and comorbid neuropsychiatric symptoms. Psychiatry research communications, 5(2), 100215. https://doi.org/10.1016/j.psycom.2025.100215 

    1. Ou, A., Wu, G. W. Y., Kassel, M. T., Mackin, R. S., Rampersaud, R., Reus, V. I., Mellon, S. H., & Wolkowitz, O. M. (2025). Cognitive function in physically healthy, unmedicated individuals with major depression: Relationship with depressive symptoms and antidepressant response. Journal of Affective Disorders. 

    1. Ye, K., Tang, H., Dai, S., Fortel, I., Thompson, P. M., Mackin, R. S., Leow, A., Huang, H., Zhan, L., & Alzheimer’s Disease Neuroimaging Initiative and the ADNI Depression Project (2025). BPEN: Brain Posterior Evidential Network for trustworthy brain imaging analysis. Neural networks : the official journal of the International Neural Network Society, 183, 106943. https://doi.org/10.1016/j.neunet.2024.106943 

    1. Manjavong, M., Diaz, A., Ashford, M. T., Aaronson, A., Miller, M. J., Kang, J. M., Mackin, S., Tank, R., Weiner, M., Nosheny, R., & Alzheimer's Disease Neuroimaging Initiative (2024). A short version of the Everyday Cognition scale can predict clinical progression and cognitive decline. Alzheimer's & dementia : the journal of the Alzheimer's Association, 20(12), 8651–8660. https://doi.org/10.1002/alz.14309 

    1. Nelson, J. C., Gandelman, J. A., & Mackin, R. S. (2025). A Systematic Review of Antidepressants and Psychotherapy Commonly Used in the Treatment of Late Life Depression for Their Effects on Cognition. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 33(3), 287–304. https://doi.org/10.1016/j.jagp.2024.08.015 

    1. Mackin, R. S., Rhodes, E., Kassel, M., Kryza-Lacombe, M., Burns, E., Bickford, D., Morin, R., Tosun, D., Landau, S., Butters, M. A., Aisen, P., Raman, R., Saykin, A. J., Toga, A., Koeppe, R., Jack, C., Weiner, M. W., Nelson, C., & Insel, P. S. (2025). Cortico-limbic volume abnormalities in late life depression are distinct from β amyloid and white matter pathologies. Molecular psychiatry, 30(4), 1267–1276. https://doi.org/10.1038/s41380-024-02677-4 

    1. Kryza-Lacombe, M., Kassel, M. T., Insel, P. S., Rhodes, E., Bickford, D., Burns, E., Butters, M. A., Tosun, D., Aisen, P., Raman, R., Saykin, A. J., Toga, A. W., Jack, C. R., Jr, Weiner, M. W., Nelson, C., & Mackin, R. S. (2024). Anxiety in late-life depression is associated with poorer performance across multiple cognitive domains. Journal of the International Neuropsychological Society : JINS, 30(9), 807–811. https://doi.org/10.1017/S1355617724000262 

    1. Jaén, C., Maute, C., Mackin, S., Camacho, M. R., Truran, D., Nosheny, R., Weiner, M. W., & Dalton, P. (2024). Remote olfactory assessment using the NIH Toolbox Odor Identification test and the brain health registry. PloS one, 19(4), e0301264. https://doi.org/10.1371/journal.pone.0301264 

    1. Tank, R., Diaz, A., Ashford, M. T., Miller, M. J., Eichenbaum, J., Aaronson, A., Landavazo, B., Neuhaus, J., Weiner, M. W., Mackin, R. S., Barnes, J., & Nosheny, R. L. (2024). Examining Demographic Factors, Psychosocial Wellbeing and Cardiovascular Health in Subjective Cognitive Decline in the Brain Health Registry Cohort. The journal of prevention of Alzheimer's disease, 11(3), 787–797. https://doi.org/10.14283/jpad.2024.39 

    1. Ashford, M. T., Jin, C., Neuhaus, J., Diaz, A., Aaronson, A., Tank, R., Eichenbaum, J., Camacho, M. R., Fockler, J., Ulbricht, A., Flenniken, D., Truran, D., Mackin, R. S., Weiner, M. W., Mindt, M. R., & Nosheny, R. L. (2024). Participant completion of longitudinal assessments in an online cognitive aging registry: The role of medical conditions. Alzheimer's & dementia (New York, N. Y.), 10(1), e12438. https://doi.org/10.1002/trc2.12438 

    1. Nutley, S., Nguyen, B. K., Mackin, R. S., Insel, P. S., Tosun, D., Butters, M., Aisen, P., Raman, R., Saykin, A. J., Toga, A. W., Jack, C., Weiner, M. W., Nelson, C., Kassel, M., Kryza-Lacombe, M., Eichenbaum, J., Nosheny, R. L., & Mathews, C. A. (2024). Relationship of Hoarding and Depression Symptoms in Older Adults. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 32(4), 497–508. https://doi.org/10.1016/j.jagp.2023.11.006 

    1. Kryza-Lacombe, M., Kassel, M. T., Insel, P. S., Rhodes, E., Bickford, D., Burns, E., Butters, M. A., Tosun, D., Aisen, P., Raman, R., Landau, S., Saykin, A. J., Toga, A. W., Jack, C. R., Jr, Koeppe, R., Weiner, M. W., Nelson, C., & Mackin, R. S. (2024). Anxiety in late-life depression: Associations with brain volume, amyloid beta, white matter lesions, cognition, and functional ability. International psychogeriatrics, 36(11), 1009–1020. https://doi.org/10.1017/S1041610224000012 

    1. Aaronson, A., Ashford, M. T., Jin, C., Bride, J., Decker, J., DeNicola, A., Turner, R. W., 2nd, Conti, C., Tank, R., Truran, D., Camacho, M. R., Fockler, J., Flenniken, D., Ulbricht, A., Grill, J. D., Rabinovici, G., Carrillo, M. C., Mackin, R. S., Weiner, M. W., & Nosheny, R. L. (2024). Brain Health Registry Study Partner Portal: Novel infrastructure for digital, dyadic data collection. Alzheimer's & dementia : the journal of the Alzheimer's Association, 20(2), 846–857. https://doi.org/10.1002/alz.13492 

    1. Ashford, M. T., Aaronson, A., Kwang, W., Eichenbaum, J., Gummadi, S., Jin, C., Cashdollar, N., Thorp, E., Wragg, E., Zavitz, K. H., Cormack, F., Banh, T., Neuhaus, J. M., Ulbricht, A., Camacho, M. R., Fockler, J., Flenniken, D., Truran, D., Mackin, R. S., Weiner, M. W., … Nosheny, R. L. (2024). Unsupervised Online Paired Associates Learning Task from the Cambridge Neuropsychological Test Automated Battery (CANTAB®) in the Brain Health Registry. The journal of prevention of Alzheimer's disease, 11(2), 514–524. https://doi.org/10.14283/jpad.2023.117 

    1. Fortel, I., Zhan, L., Ajilore, O., Wu, Y., Mackin, S., & Leow, A. (2023). Disrupted Excitation-Inhibition Balance in Cognitively Normal Individuals at Risk of Alzheimer's Disease. Journal of Alzheimer's disease : JAD, 95(4), 1449–1467. https://doi.org/10.3233/JAD-230035 

    1. Kassel, M. T., Kryza-Lacombe, M., Insel, P. S., Rhodes, E., Satre, D. D., Nelson, J. C., Tosun, D., Mathews, C. A., & Mackin, R. S. (2024). Hoarding Symptoms in Late Life Depression are Associated With Greater Executive Dysfunction and Disability and Poorer Response to Depression Treatment. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 32(2), 137–147. https://doi.org/10.1016/j.jagp.2023.08.009 

    1. Kamath, V., Jiang, K., Manning, K. J., Mackin, R. S., Walker, K. A., Powell, D., Lin, F. R., Chen, H., Brenowitz, W. D., Yaffe, K., Simonsick, E. M., & Deal, J. A. (2024). Olfactory Dysfunction and Depression Trajectories in Community-Dwelling Older Adults. The journals of gerontology. Series A, Biological sciences and medical sciences, 79(1), glad139. https://doi.org/10.1093/gerona/glad139 

    1. Nosheny, R. L., Yen, D., Howell, T., Camacho, M., Moulder, K., Gummadi, S., Bui, C., Kannan, S., Ashford, M., Knight, K., Mayo, C., McMillan, M., Petersen, R. C., Stricker, N. H., Roberson, E. D., Chambless, C., Gersteneker, A., Martin, R., Kennedy, R., Zhang, Y., Kukull, W., Flenniken, D., Fockler, J., Truran, D., Mackin, R. S., Weiner, M. W., Morris, J. C., & Li, Y. (2023). Evaluation of the electronic Clinical Dementia Rating for dementia screening. JAMA Network Open, 6(10), e2333786. https://doi.org/10.1001/jamanetworkopen.2023.33786 

    1. Jakary, A., Lupo, J. M., Mackin, S., Yin, A., Murray, D., Yang, T., Mukherjee, P., Larson, P., Xu, D., Eisendrath, S., Luks, T., & Li, Y. (2023). Evaluation of major depressive disorder using 7 Tesla phase sensitive neuroimaging before and after mindfulness-based cognitive therapy. Journal of affective disorders, 335, 383–391. https://doi.org/10.1016/j.jad.2023.05.038 

    1. Gerstenecker, A., Kennedy, R., Zhang, Y., Martin, R. C., Mackin, R. S., Weiner, M. W., Howell, T., Petersen, R. C., Roberson, E. D., & Marson, D. C. (2023). Item Response Analysis of the Financial Capacity Instrument-Short Form. Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists, 38(5), 739–758. https://doi.org/10.1093/arclin/acac112 

    1. Ashford, M. T., Camacho, M. R., Jin, C., Eichenbaum, J., Ulbricht, A., Alaniz, R., Van De Mortel, L., Sorce, J., Aaronson, A., Parmar, S., Flenniken, D., Fockler, J., Truran, D., Mackin, R. S., Rivera Mindt, M., Morlett-Paredes, A., González, H. M., Mayeda, E. R., Weiner, M. W., & Nosheny, R. L. (2023). Digital culturally tailored marketing for enrolling Latino participants in a web-based registry: Baseline metrics from the Brain Health Registry. Alzheimer's & dementia : the journal of the Alzheimer's Association, 19(5), 1714–1728. https://doi.org/10.1002/alz.12805 

    1. Ashford, M. T., Eichenbaum, J., Jin, C., Neuhaus, J., Aaronson, A., Ulbricht, A., Camacho, M. R., Fockler, J., Flenniken, D., Truran, D., Mackin, R. S., Maruff, P., Weiner, M. W., & Nosheny, R. L. (2023). Associations between Participant Characteristics and Participant Feedback about an Unsupervised Online Cognitive Assessment in a Research Registry. The journal of prevention of Alzheimer's disease, 10(3), 607–614. https://doi.org/10.14283/jpad.2023.40 

    1. Mackin, R. S., Jin, C., Burns, E., Kassel, M., Rhodes, E., Nosheny, R., Ashford, M., Banh, T., Eichenbaum, J., Knight, K., Tank, R., Camacho, M. R., Fockler, J., Truran, D., Neuhaus, J., & Weiner, M. (2023). Association of Major Depressive Disorder with remotely administered measures of cognition and subjective report of cognitive difficulties across the adult age spectrum. Journal of affective disorders, 326, 198–205. https://doi.org/10.1016/j.jad.2022.12.045 

    1. Mindt, M. R., Ashford, M. T., Zhu, D., Cham, H., Aaronson, A., Conti, C., Deng, X., Alaniz, R., Sorce, J., Cypress, C., Griffin, P., Flenniken, D., Camacho, M., Fockler, J., Truran, D., Mackin, R. S., Hill, C., Weiner, M. W., Byrd, D., Turner Ii, R. W., … Nosheny, R. L. (2023). The Community Engaged Digital Alzheimer's Research (CEDAR) Study: A Digital Intervention to Increase Research Participation of Black American Participants in the Brain Health Registry. The journal of prevention of Alzheimer's disease, 10(4), 847–856. https://doi.org/10.14283/jpad.2023.32 

    1. Weiner, M. W., Aaronson, A., Eichenbaum, J., Kwang, W., Ashford, M. T., Gummadi, S., Santhakumar, J., Camacho, M. R., Flenniken, D., Fockler, J., Truran-Sacrey, D., Ulbricht, A., Mackin, R. S., & Nosheny, R. L. (2023). Brain health registry updates: An online longitudinal neuroscience platform. Alzheimer's & dementia : the journal of the Alzheimer's Association, 19(11), 4935–4951. https://doi.org/10.1002/alz.13077 

    1. Nosheny, R. L., Jin, C., Knight, K. N., Banh, T., Howell, T., Truran-Sacrey, D., Fockler, J., Bui, C. L., Gummadi, S. L., Santhakumar, J., Ashford, M. T., Camacho, M. R., Flenniken, D., Roberson, E. D., Morris, J. C., Moulder, K. L., Li, R., Petersen, R. C., Strickler, N. H., Rabinovici, G. D., Carrillo, M. C., Neuhaus, J., Mackin, R. S., & Weiner, M. W. (2022). Contributions of remote, unsupervised dyadic subjective measures to identify older adults with mild cognitive impairment. Alzheimer’s & Dementia, 18(S1), S7. 

    1. Kassam, F., Chen, H., Nosheny, R. L., McGirr, A., Williams, T., Ng, N., Camacho, M., Mackin, R. S., Weiner, M. W., & Ismail, Z. (2023). Cognitive profile of people with mild behavioral impairment in Brain Health Registry participants. International psychogeriatrics, 35(11), 643–652. https://doi.org/10.1017/S1041610221002878 

    1. Myoraku, A., Lang, A., Taylor, C. T., Scott Mackin, R., Meyerhoff, D. J., Mueller, S., Strigo, I. A., & Tosun, D. (2022). Age-dependent brain morphometry in Major Depressive disorder. NeuroImage. Clinical, 33, 102924. https://doi.org/10.1016/j.nicl.2021.102924 

    1. Ashford, M. T., Eichenbaum, J., Jin, C., Neuhaus, J., Ulbricht, A., Camacho, M. R., Fockler, J., Flenniken, D., Truran-Sacrey, D., Mackin, R. S., Maruff, P., Weiner, M. W., & Nosheny, R. L. (2022). Participant experience in a longitudinal online research registry: Associations between ethnocultural identity, educational attainment, and participant feedback in the Brain Health Registry. Alzheimer’s & Dementia, 18(S11). 

    1. Nutley, S. K., Read, M., Martinez, S., Eichenbaum, J., Nosheny, R. L., Weiner, M., Mackin, R. S., & Mathews, C. A. (2022). Hoarding symptoms are associated with higher rates of disability than other medical and psychiatric disorders across multiple domains of functioning. BMC psychiatry, 22(1), 647. https://doi.org/10.1186/s12888-022-04287-2 

    1. Nutley, S. K., Read, M., Eichenbaum, J., Nosheny, R. L., Weiner, M., Mackin, R. S., & Mathews, C. A. (2022). Health-related quality of life in hoarding: A comparison to chronic conditions with high disease burden. Journal of psychiatric research, 149, 68–75. https://doi.org/10.1016/j.jpsychires.2022.02.035 

    1. Sordo Vieira, L., Guastello, A., Nguyen, B., Nutley, S. K., Ordway, A., Simpson, H., Zakrzewski, J., Archer, C., Liu, N., Jean Gilles, M. E., Nosheny, R., Weiner, M., Mackin, R. S., & Mathews, C. A. (2022). Identifying psychiatric and neurological comorbidities associated with hoarding disorder through network analysis. Journal of psychiatric research, 156, 16–24. https://doi.org/10.1016/j.jpsychires.2022.09.037 

    1. Fockler, J., Ashford, M. T., Eichenbaum, J., Howell, T., Ekanem, A., Flenniken, D., Happ, A., Truran, D., Mackin, R. S., Blennow, K., Halperin, E., Coppola, G., Weiner, M. W., & Nosheny, R. L. (2022). Remote blood collection from older adults in the Brain Health Registry for plasma biomarker and genetic analysis. Alzheimer's & dementia : the journal of the Alzheimer's Association, 18(12), 2627–2636. https://doi.org/10.1002/alz.12617 

    1. Kassel, M. T., Rhodes, E., Insel, P. S., Woodworth, K., Garrison-Diehn, C., Satre, D. D., Nelson, J. C., Tosun, D., & Mackin, R. S. (2022). Cognitive outcomes are differentially associated with depression severity trajectories during psychotherapy treatment for late life major depressive disorder. International journal of geriatric psychiatry, 37(8), 10.1002/gps.5779. https://doi.org/10.1002/gps.5779 

    1. Sordo Vieira, L., Nguyen, B., Nutley, S. K., Bertolace, L., Ordway, A., Simpson, H., Zakrzewski, J., Jean Gilles, M. E., Nosheny, R., Weiner, M., Mackin, R. S., & Mathews, C. A. (2022). Self-reporting of psychiatric illness in an online patient registry is a good indicator of the existence of psychiatric illness. Journal of psychiatric research, 151, 34–41. https://doi.org/10.1016/j.jpsychires.2022.03.022 

    1. Chen, K., Goradia, D. D., Chen, Y., Luo, J., Devadas, V., Jagust, W. J., Mackin, R. S., Su, Y., Landau, S. M., Weiner, M. W., & Reiman, E. M. (2022). Serotonin reuptake inhibitors are associated with less amyloid beta burden spatial extent in military veterans with only PTSD, but not with TBI or comorbid PTSD/TBI: Preliminary PET findings from ADNI-DOD Project. Alzheimer’s & Dementia, 18(S6). 

    1. Mackin, R. S., Rhodes, E., Insel, P. S., Nosheny, R., Finley, S., Ashford, M., Camacho, M. R., Truran, D., Mosca, K., Seabrook, G., Morrison, R., Narayan, V. A., & Weiner, M. (2022). Reliability and Validity of a Home-Based Self-Administered Computerized Test of Learning and Memory Using Speech Recognition. Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition, 29(5), 867–881. https://doi.org/10.1080/13825585.2021.1927961 

    1. Gonzales, M. M., Samra, J., O'Donnell, A., Mackin, R. S., Salinas, J., Jacob, M. E., Satizabal, C. L., Aparicio, H. J., Thibault, E. G., Sanchez, J. S., Finney, R., Rubinstein, Z. B., Mayblyum, D. V., Killiany, R. J., Decarli, C. S., Johnson, K. A., Beiser, A. S., & Seshadri, S. (2021). Association of Midlife Depressive Symptoms with Regional Amyloid-β and Tau in the Framingham Heart Study. Journal of Alzheimer's disease : JAD, 82(1), 249–260. https://doi.org/10.3233/JAD-210232 

    1. Insel, P. S., Mohlenhoff, B. S., Neylan, T. C., Krystal, A. D., & Mackin, R. S. (2021). Association of Sleep and β-Amyloid Pathology Among Older Cognitively Unimpaired Adults. JAMA network open, 4(7), e2117573. https://doi.org/10.1001/jamanetworkopen.2021.17573 

    1. Albright, J., Ashford, M. T., Jin, C., Neuhaus, J., Rabinovici, G. D., Truran, D., Maruff, P., Mackin, R. S., Nosheny, R. L., & Weiner, M. W. (2021). Machine learning approaches to predicting amyloid status using data from an online research and recruitment registry: The Brain Health Registry. Alzheimer's & dementia (Amsterdam, Netherlands), 13(1), e12207. https://doi.org/10.1002/dad2.12207 

    1. Lutz, J., Mackin, R. S., Otero, M. C., Morin, R., Bickford, D., Tosun, D., Satre, D. D., Gould, C. E., Nelson, J. C., & Beaudreau, S. A. (2021). Improvements in Functional Disability After Psychotherapy for Depression Are Associated With Reduced Suicide Ideation Among Older Adults. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 29(6), 557–561. https://doi.org/10.1016/j.jagp.2020.09.021 

    1. Rhodes, E., Insel, P. S., Butters, M. A., Morin, R., Bickford, D., Tosun, D., Gessert, D., Rosen, H. J., Aisen, P., Raman, R., Landau, S., Saykin, A., Toga, A., Jack, C. R., Weiner, M. W., Nelson, C., Mackin, S., Alzheimer’s Disease Neuroimaging Initiative, & ADNI Depression Project (2021). The Impact of Amyloid Burden and APOE on Rates of Cognitive Impairment in Late Life Depression. Journal of Alzheimer's disease : JAD, 80(3), 991–1002. https://doi.org/10.3233/JAD-201089 

    1. Nutley, S. K., Camacho, M. R., Eichenbaum, J., Nosheny, R. L., Weiner, M., Delucchi, K. L., Mackin, R. S., & Mathews, C. A. (2021). Hoarding disorder is associated with self-reported cardiovascular / metabolic dysfunction, chronic pain, and sleep apnea. Journal of psychiatric research, 134, 15–21. https://doi.org/10.1016/j.jpsychires.2020.12.032 

    1. Mackin, R. S., Insel, P. S., Landau, S., Bickford, D., Morin, R., Rhodes, E., Tosun, D., Rosen, H. J., Butters, M., Aisen, P., Raman, R., Saykin, A., Toga, A., Jack, C., Jr, Koeppe, R., Weiner, M. W., Nelson, C., & Alzheimer’s Disease Neuroimaging Initiative and the ADNI Depression Project (2021). Late-Life Depression Is Associated With Reduced Cortical Amyloid Burden: Findings From the Alzheimer's Disease Neuroimaging Initiative Depression Project. Biological psychiatry, 89(8), 757–765. https://doi.org/10.1016/j.biopsych.2020.06.017 

    1. Fockler, J., Kwang, W., Ashford, M. T., Flenniken, D., Hwang, J., Truran, D., Mackin, R. S., Jin, C., O'Hara, R., Hallmayer, J. F., Yesavage, J. A., Weiner, M. W., & Nosheny, R. L. (2021). Brain health registry GenePool study: A novel approach to online genetics research. Alzheimer's & dementia (New York, N. Y.), 7(1), e12118. https://doi.org/10.1002/trc2.12118 

    1. Bickford, D., Morin, R. T., Woodworth, C., Verduzco, E., Khan, M., Burns, E., Nelson, J. C., & Mackin, R. S. (2021). The relationship of frailty and disability with suicidal ideation in late life depression. Aging & mental health, 25(3), 439–444. https://doi.org/10.1080/13607863.2019.1698514 

    1. Nutley, S. K., Bertolace, L., Vieira, L. S., Nguyen, B., Ordway, A., Simpson, H., Zakrzewski, J., Camacho, M. R., Eichenbaum, J., Nosheny, R., Weiner, M., Mackin, R. S., & Mathews, C. A. (2020). Internet-based hoarding assessment: The reliability and predictive validity of the internet-based Hoarding Rating Scale, Self-Report. Psychiatry research, 294, 113505. https://doi.org/10.1016/j.psychres.2020.113505 

    1. Nosheny, R. L., Camacho, M. R., Jin, C., Neuhaus, J., Truran, D., Flenniken, D., Ashford, M., Carrillo, M. C., Fargo, K. N., Hendrix, J., Hanna, L., Rabinovici, G., Maruff, P., Mackin, R. S., & Weiner, M. W. (2020). Validation of online functional measures in cognitively impaired older adults. Alzheimer's & dementia : the journal of the Alzheimer's Association, 16(10), 1426–1437. https://doi.org/10.1002/alz.12138 

    1. Ashford, M. T., Neuhaus, J., Jin, C., Camacho, M. R., Fockler, J., Truran, D., Mackin, R. S., Rabinovici, G. D., Weiner, M. W., & Nosheny, R. L. (2020). Predicting amyloid status using self-report information from an online research and recruitment registry: The Brain Health Registry. Alzheimer's & dementia (Amsterdam, Netherlands), 12(1), e12102. https://doi.org/10.1002/dad2.12102 

    1. Alosco, M. L., Tripodis, Y., Baucom, Z. H., Mez, J., Stein, T. D., Martin, B., Haller, O., Conneely, S., McClean, M., Nosheny, R., Mackin, S., McKee, A. C., Weiner, M. W., & Stern, R. A. (2020). Late contributions of repetitive head impacts and TBI to depression symptoms and cognition. Neurology, 95(7), e793–e804. https://doi.org/10.1212/WNL.0000000000010040 

    1. Morin, R. T., Nelson, C., Bickford, D., Insel, P. S., & Mackin, R. S. (2020). Somatic and anxiety symptoms of depression are associated with disability in late life depression. Aging & mental health, 24(8), 1225–1228. https://doi.org/10.1080/13607863.2019.1597013 

    1. Morin, R. T., Insel, P., Bickford, D., Nelson, C., & Mackin, R. S. (2020). Depression Severity, but Not Cognitive Impairment or Frailty, is Associated with Disability in Late-Life Depression. Clinical gerontologist, 43(4), 411–419. https://doi.org/10.1080/07317115.2019.1699882 

    1. Ashford, M. T., Eichenbaum, J., Williams, T., Camacho, M. R., Fockler, J., Ulbricht, A., Flenniken, D., Truran, D., Mackin, R. S., Weiner, M. W., & Nosheny, R. L. (2020). Effects of sex, race, ethnicity, and education on online aging research participation. Alzheimer's & dementia (New York, N. Y.), 6(1), e12028. https://doi.org/10.1002/trc2.12028 

    1. J Zakrzewski, J., A Gillett, D., R Vigil, O., C Smith, L., Komaiko, K., Chou, C. Y., Y Uhm, S., Bain, L. D., J Stark, S., Gause, M., Howell, G., Vega, E., Chan, J., B Eckfield, M., Y Tsoh, J., Delucchi, K., Mackin, R. S., & A Mathews, C. (2020). Visually mediated functioning improves following treatment of hoarding disorder. Journal of affective disorders, 264, 310–317. https://doi.org/10.1016/j.jad.2019.12.030 

    1. Bickford, D., Morin, R. T., Nelson, J. C., & Mackin, R. S. (2020). Determinants of Suicide-related Ideation in Late Life Depression: Associations with Perceived Stress. Clinical gerontologist, 43(1), 37–45. https://doi.org/10.1080/07317115.2019.1666442 

    1. Nosheny, R. L., Jin, C., Neuhaus, J., Insel, P. S., Mackin, R. S., Weiner, M. W., & Alzheimer’s Disease Neuroimaging Initiative investigators (2019). Study partner-reported decline identifies cognitive decline and dementia risk. Annals of clinical and translational neurology, 6(12), 2448–2459. https://doi.org/10.1002/acn3.50938 

    1. Morin, R. T., Li, Y., Mackin, R. S., Whooley, M. A., Conwell, Y., & Byers, A. L. (2019). Comorbidity Profiles Identified in Older Primary Care Patients Who Attempt Suicide. Journal of the American Geriatrics Society, 67(12), 2553–2559. https://doi.org/10.1111/jgs.16126 

    1. Morin, R. T., Gonzales, M. M., Bickford, D., Catalinotto, D., Nelson, C., & Mackin, R. S. (2019). Impaired Financial Capacity in Late-Life Depression: Revisiting Associations with Cognitive Functioning. Journal of the International Neuropsychological Society : JINS, 25(10), 1088–1093. https://doi.org/10.1017/S1355617719000705 

    1. Jain, F. A., Connolly, C. G., Reus, V. I., Meyerhoff, D. J., Yang, T. T., Mellon, S. H., Mackin, S., Hough, C. M., Morford, A., & Wolkowitz, O. M. (2019). Cortisol, moderated by age, is associated with antidepressant treatment outcome and memory improvement in Major Depressive Disorder: A retrospective analysis. Psychoneuroendocrinology, 109, 104386. https://doi.org/10.1016/j.psyneuen.2019.104386 

    1. Morin, R. T., Insel, P., Nelson, C., Butters, M., Bickford, D., Landau, S., Saykin, A., Weiner, M., Mackin, R. S., & ADNI Depression Project (2019). Latent Classes of Cognitive Functioning Among Depressed Older Adults Without Dementia. Journal of the International Neuropsychological Society : JINS, 25(8), 811–820. https://doi.org/10.1017/S1355617719000596 

    1. Insel, P. S., Weiner, M., Mackin, R. S., Mormino, E., Lim, Y. Y., Stomrud, E., Palmqvist, S., Masters, C. L., Maruff, P. T., Hansson, O., & Mattsson, N. (2019). Determining clinically meaningful decline in preclinical Alzheimer disease. Neurology, 93(4), e322–e333. https://doi.org/10.1212/WNL.0000000000007831 

    1. Archer, C. A., Moran, K. M., Garza, K. A., Zakrzewski, A. M., Chou, C., Uhm, S. Y., Chan, J., Gause, M., Salazar, M., Plumadore, J., Smith, L. C., Komaiko, K., Howell, G., Vigil, O., Bain, D., Stark, S., Mackin, R. S., Eckfield, M., Vega, E., Tsoh, J. Y., Delucchi, K. L., & Mathews, C. A. (2019). Relationship between symptom severity, psychiatric comorbidity, social/occupational impairment, and suicidality in hoarding disorder. Journal of Obsessive-Compulsive and Related Disorders, 21, 158–164. 

    1. Cholerton, B., Weiner, M. W., Nosheny, R. L., Poston, K. L., Mackin, R. S., Tian, L., Ashford, J. W., & Montine, T. J. (2019). Cognitive Performance in Parkinson's Disease in the Brain Health Registry. Journal of Alzheimer's disease : JAD, 68(3), 1029–1038. https://doi.org/10.3233/JAD-181009 

    1. Martin, A. M., Zakrzewski, J. J., Chou, C. Y., Uhm, S. Y., Gause, R. M., Chan, J., Eckfield, M., Salazar, M., Vigil, O., Bain, D., Stark, S. J., Mackin, R. S., Vega, E., Delucchi, K. L., Tsoh, J. Y., & Mathews, C. A. (2018). Recruiting under-represented populations into psychiatric research: Results from the help for hoarding study. Contemporary clinical trials communications, 12, 169–175. https://doi.org/10.1016/j.conctc.2018.11.003 

    1. Nosheny, R. L., Camacho, M. R., Insel, P. S., Flenniken, D., Fockler, J., Truran, D., Finley, S., Ulbricht, A., Maruff, P., Yaffe, K., Mackin, R. S., & Weiner, M. W. (2018). Online study partner-reported cognitive decline in the Brain Health Registry. Alzheimer's & dementia (New York, N. Y.), 4, 565–574. https://doi.org/10.1016/j.trci.2018.09.008 

    1. Bickford, D., Morin, R. T., Catalinotto, D., Mackin, R. S., & Nelson, J. C. (2018). Screening for Executive Dysfunction in Late-Life Depression: Utility of Trail Making Test and Self-Report Measures. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 26(10), 1091–1094. https://doi.org/10.1016/j.jagp.2018.06.006 

    1. Gonzales, M. M., Insel, P. S., Nelson, C., Tosun, D., Schöll, M., Mattsson, N., Sacuiu, S., Bickford, D., Weiner, M. W., Mackin, R. S., & Alzheimer's Disease Neuroimaging Initiative (2018). Chronic depressive symptomatology and CSF amyloid beta and tau levels in mild cognitive impairment. International journal of geriatric psychiatry, 33(10), 1305–1311. https://doi.org/10.1002/gps.4926 

    1. Mohlenhoff, B. S., Insel, P. S., Mackin, R. S., Neylan, T. C., Flenniken, D., Nosheny, R., Richards, A., Maruff, P., & Weiner, M. W. (2018). Total Sleep Time Interacts With Age to Predict Cognitive Performance Among Adults. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 14(9), 1587–1594. https://doi.org/10.5664/jcsm.7342 

    1. Chou, C. Y., Mackin, R. S., Delucchi, K. L., & Mathews, C. A. (2018). Detail-oriented visual processing style: Its role in the relationships between early life adversity and hoarding-related dysfunctions. Psychiatry research, 267, 30–36. https://doi.org/10.1016/j.psychres.2018.05.053 

    1. Weiner, M. W., Nosheny, R., Camacho, M., Truran-Sacrey, D., Mackin, R. S., Flenniken, D., Ulbricht, A., Insel, P., Finley, S., Fockler, J., & Veitch, D. (2018). The Brain Health Registry: An internet-based platform for recruitment, assessment, and longitudinal monitoring of participants for neuroscience studies. Alzheimer's & dementia : the journal of the Alzheimer's Association, 14(8), 1063–1076. https://doi.org/10.1016/j.jalz.2018.02.021 

    1. Mathews, C. A., Mackin, R. S., Chou, C. Y., Uhm, S. Y., Bain, L. D., Stark, S. J., Gause, M., Vigil, O. R., Franklin, J., Salazar, M., Plumadore, J., Smith, L. C., Komaiko, K., Howell, G., Vega, E., Chan, J., Eckfield, M. B., Tsoh, J. Y., & Delucchi, K. (2018). Randomised clinical trial of community-based peer-led and psychologist-led group treatment for hoarding disorder. BJPsych open, 4(4), 285–293. https://doi.org/10.1192/bjo.2018.30 

    1. Mackin, R. S., Insel, P. S., Truran, D., Finley, S., Flenniken, D., Nosheny, R., Ulbright, A., Comacho, M., Bickford, D., Harel, B., Maruff, P., & Weiner, M. W. (2018). Unsupervised online neuropsychological test performance for individuals with mild cognitive impairment and dementia: Results from the Brain Health Registry. Alzheimer's & dementia (Amsterdam, Netherlands), 10, 573–582. https://doi.org/10.1016/j.dadm.2018.05.005 

    1. Satre, D. D., Bahorik, A. L., & Mackin, R. S. (2018). Alcohol and Drug Use Among Older Adults: Associations with Widowhood, Relationship Quality, and Physical Health. The journals of gerontology. Series B, Psychological sciences and social sciences, 73(4), 633–635. https://doi.org/10.1093/geronb/gbx158 

    1. Insel, P. S., Hansson, O., Mackin, R. S., Weiner, M., Mattsson, N., & Alzheimer's Disease Neuroimaging Initiative (2018). Amyloid pathology in the progression to mild cognitive impairment. Neurobiology of aging, 64, 76–84. https://doi.org/10.1016/j.neurobiolaging.2017.12.018 

    1. Gonzales, M. M., Insel, P. S., Nelson, C., Tosun, D., Mattsson, N., Mueller, S. G., Sacuiu, S., Bickford, D., Weiner, M. W., Mackin, R. S., & Alzheimer's Disease Neuroimaging Initiative (2017).  Cortical Atrophy is Associated with Accelerated Cognitive Decline in Mild Cognitive Impairment with Subsyndromal Depression. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 25(9), 980–991. https://doi.org/10.1016/j.jagp.2017.04.011 

    1. Insel, P. S., Donohue, M. C., Mackin, R. S., Aisen, P. S., Hansson, O., Weiner, M. W., Mattsson, N., & Alzheimer's Disease Neuroimaging Initiative (2016). Cognitive and functional changes associated with Aβ pathology and the progression to mild cognitive impairment. Neurobiology of aging, 48, 172–181. https://doi.org/10.1016/j.neurobiolaging.2016.08.017 

    1. Uhm, S. Y., Tsoh, J. Y., Mackin, R. S., Gause, M., Chan, J., Franklin, J., Eckfield, M., Salazar, M., Vigil, O., Bain, D., Stark, S., Vega, E., Delucchi, K. L., & Mathews, C. A. (2016). Comparison of a peer facilitated support group to cognitive behavior therapy: Study protocol for a randomized controlled trial for hoarding disorder. Contemporary clinical trials, 50, 98–105. https://doi.org/10.1016/j.cct.2016.07.018 

    1. Insel, P. S., Palmqvist, S., Mackin, R. S., Nosheny, R. L., Hansson, O., Weiner, M. W., & Mattsson, N. (2016). Assessing risk for preclinical β-amyloid pathology with APOE, cognitive, and demographic information. Alzheimer's & dementia (Amsterdam, Netherlands), 4, 76–84. https://doi.org/10.1016/j.dadm.2016.07.002 

    1. Insel, P. S., Mattsson, N., Mackin, R. S., Scholl, M., Nosheny, R., Tosun-Turgut, D., Donohue, M. C., Aisen, P. S., Jagust, W. J., Weiner, M. W., & Alzheimer’s Disease Neuroimaging Initiative. (2016). Accelerating rates of cognitive decline and imaging biomarkers associated with beta-amyloid pathology. Neurology, 86(20), 1887–1896. 

    1. Mackin, R. S., Vigil, O., Insel, P., Kivowitz, A., Kupferman, E., Hough, C. M., Fekri, S., Crothers, R., Bickford, D., Delucchi, K. L., & Mathews, C. A. (2016). PATTERNS OF CLINICALLY SIGNIFICANT COGNITIVE IMPAIRMENT IN HOARDING DISORDER. Depression and anxiety, 33(3), 211–218. https://doi.org/10.1002/da.22439 

    1. Sacuiu, S., Insel, P. S., Mueller, S., Tosun, D., Mattsson, N., Jack, C. R., Jr, DeCarli, C., Petersen, R., Aisen, P. S., Weiner, M. W., Mackin, R. S., & Alzheimer's Disease Neuroimaging Initiative (2016). Chronic Depressive Symptomatology in Mild Cognitive Impairment Is Associated with Frontal Atrophy Rate which Hastens Conversion to Alzheimer Dementia. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 24(2), 126–135. https://doi.org/10.1016/j.jagp.2015.03.006 

    1. Mueller, S. G., Ng, P., Neylan, T., Mackin, S., Wolkowitz, O., Mellon, S., Yan, X., Flory, J., Yehuda, R., Marmar, C. R., & Weiner, M. W. (2015). Evidence for disrupted gray matter structural connectivity in posttraumatic stress disorder. Psychiatry research, 234(2), 194–201. https://doi.org/10.1016/j.pscychresns.2015.09.006 

    1. Insel, P. S., Mattsson, N., Donohue, M. C., Mackin, R. S., Aisen, P. S., Jack, C. R., Jr, Shaw, L. M., Trojanowski, J. Q., Weiner, M. W., & Alzheimer's Disease Neuroimaging Initiative (2015). The transitional association between β-amyloid pathology and regional brain atrophy. Alzheimer's & dementia : the journal of the Alzheimer's Association, 11(10), 1171–1179. https://doi.org/10.1016/j.jalz.2014.11.002 

    1. Jack, C. R., Jr., Barnes, J., Bernstein, M. A., Borowski, B. J., Brewer, J., Clegg, S., Dale, A. M., Carmichael, O., Ching, C., DeCarli, C., Desikan, R. S., Fennema-Notestine, C., Fjell, A. M., Fletcher, E., Fox, N. C., Gunter, J., Gutman, B. A., Holland, D., Hua, X., Insel, P., Kantarci, K., Killiany, R. J., Krueger, G., Leung, K. K., Mackin, S., Maillard, P., Malone, I. B., Mattsson, N., McEvoy, L., Modat, M., Mueller, S., Nosheny, R., Ourselin, S., Schuff, N., Senjem, M. L., Simonson, A., Thompson, P. M., Rettmann, D., Vemuri, P., Walhovd, K., Zhao, Y., Zuk, S., & Weiner, M. (2015). Magnetic resonance imaging in Alzheimer’s Disease Neuroimaging Initiative 2. Alzheimer’s & Dementia, 11(7), 740–756. https://doi.org/10.1016/j.jalz.2015.05.002 

    1. Geyer, J., Insel, P., Farzin, F., Sternberg, D., Hardy, J. L., Scanlon, M., Mungas, D., Kramer, J., Mackin, R. S., & Weiner, M. W. (2015). Evidence for age-associated cognitive decline from Internet game scores. Alzheimer's & dementia (Amsterdam, Netherlands), 1(2), 260–267. https://doi.org/10.1016/j.dadm.2015.04.002 

    1. Peskin, V. A., Ordóñez, A., Mackin, R. S., Delucchi, K., Monge, S., McGough, J. J., Chavira, D. A., Berrocal, M., Cheung, E., Fournier, E., Badner, J. A., Herrera, L. D., & Mathews, C. A. (2015). Neuropsychological and dimensional behavioral trait profiles in Costa Rican ADHD sib pairs: Potential intermediate phenotypes for genetic studies. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 168B(4), 247–257. https://doi.org/10.1002/ajmg.b.32305 

    1. Insel, P. S., Mattsson, N., Mackin, R. S., Kornak, J., Nosheny, R., Tosun-Turgut, D., Donohue, M. C., Aisen, P. S., Weiner, M. W., & Alzheimer's Disease Neuroimaging Initiative (2015). Biomarkers and cognitive endpoints to optimize trials in Alzheimer's disease. Annals of clinical and translational neurology, 2(5), 534–547. https://doi.org/10.1002/acn3.192 

    1. Wolkowitz, O. M., Mellon, S. H., Lindqvist, D., Epel, E. S., Blackburn, E. H., Lin, J., Reus, V. I., Burke, H., Rosser, R., Mahan, L., Mackin, S., Yang, T., Weiner, M., & Mueller, S. (2015). PBMC telomerase activity, but not leukocyte telomere length, correlates with hippocampal volume in major depression. Psychiatry research, 232(1), 58–64. https://doi.org/10.1016/j.pscychresns.2015.01.007 

    1. Mattsson, N., Insel, P., Aisen, P. S., Jagust, W., Mackin, R. S., & Weiner, M. W. for the Alzheimer’s Disease Neuroimaging Initiative. (2015). Brain structure and function as mediators of the effects of amyloid on memory. Neurology, 84(11), 1136–1144. 

    1. Mackin, R. S., Insel, P., Zhang, J., Mohlenhoff, B., Galasko, D., Weiner, M., & Mattsson, N. (2015). Cerebrospinal fluid α-synuclein and Lewy body-like symptoms in normal controls, mild cognitive impairment, and Alzheimer's disease. Journal of Alzheimer's disease : JAD, 43(3), 1007–1016. https://doi.org/10.3233/JAD-141287

For more publications by the lab, please visit: https://pubmed.ncbi.nlm.nih.gov/?term=mackin+scott&sort=date