Research

 

Presentations in 2017

  1. Grand Round: Depression In Alzheimer’s Disease: Cause or Consequence, Stanford Medicine, Department of Psychiatry and Behavioral Science, Palo Alto, CA (Scott Mackin, PhD)
  2. Conference Lecture: Management of Late Life Depression, Anxiety and Depression Association of America Conference, San Francisco, CA. (Craig Nelson, MD)
  3. Community Presentation: Depression In Alzheimer’s Disease: Cause or Consequence, Rossmoor: Northern California’s Active Senior Adult Community, Walnut Creek, CA (Scott Mackin, PhD)
  4. AAGP Symposium Session: Cognitive Impairment in Late LIfe Depression. Symposium session presented at the annual meeting of the American Association of Geriatric Psychiatry. Dallas, TX.
    1. Cognitive problems in late life depression: What are they, how common, and what is their impact. (Craig Nelson, MD)
    2. Cognitive dysfunction in Late Life Depression: Association with markers of neurodegeneration. (Scott Mackin, PhD)
    3. Spread of Late Life Depression pathophysiology on neural circuits. (Duygu Tosun-Turgut, PhD

                                                                                                                                                                                                        

 

Posters

  1. Mackin, R. S., Insel, P., Neqlson, C., Tosun, D., Gonzales, M. M., Bickford, D., Mueller, S., Weiner, M. W., ADNI (2016). Cortial Atrophy is Associated with Accelerated Cognitive Decline in Mild Cognitive Impairment with Subsyndromal Depression. Poster presented at the 9th Edition of Clincal Trial on Alzheimer's Disease. San Diego, CA.

  2. Gonzales, M., Insel, Mattsson, Mueller, Sacuiu, Bickford, Nelson, C., Tosun, D., Weiner, Mackin, R.S. (2016). Association of Subsyndromal Symptoms of Depression with Cognitive Decline and Cortical Atrophy in Individuals with Mild Cognitive Impairment. Poster presented at the 9th Edition of Clincal Trial on Alzheimer's Disease. San Diego, CA.

  3. Au, Y., Farley, K., Bickford, Scherer, K., Nelson, C., Mackin, R. S., Tosun, D., Sadeghi, R. (2016). Effects of Social Support on Treatment Response on Late Life Depression. Poster presented at the IPA international Congress. San Francisco, CA.

  4. Scherer, K., Bickford, D., Au, Y., Farley, K., Mackin, R. S., Tosun-Turget, D., Weiner, M., Nelson, C., Satre, D. (2016). Structural Changes in the Brain in Response to Psychotherapeutic Treatment. Poster presented at the IPA international Congress. San Francisco, CA.

  5. Farley, K., Bickford, D., Au, Y., Scherer, K., Crocker, N., Nelson, C., Mackin, R. S., Tosun, D. (2016). Cortical Thickness and Executive Function in Late Life Depression. Poster presented at the IPA international Congress. San Francisco, CA.

  6. Nelson, C., Bickford, N., Mackin, R. S. (2015). The Utility of Patient Reported Cognitve Impairment in Late Life Depression. Poster presented at the International Society for CNS Clinical Trials and Methodology Autumn Conference. Amsterdam, NL.

  7. Pisner, D., Kivowitz, A., Bickford, D., Tegenkamp, K., Crothers, R., Nelson, C., Mackin, R. S. (2014) Sleep Disturbances as a Risk Factor for Memory Deficits in Late Life Depression. Poster Presented at the American Psychiatric Association Annual Meeting. New York, NY.

  8. Bickford, B., Kivowitz, A., Pisner, D., Tegenkamp, K., Crothers, R., Nelson, C., Mackin, R.S. (2014). Assocaition of Cognitive Outcomes and Response Status in Late Life Depression" A 12 Month Longitudinal Study. Poster Presented at the American Psychiatric Association Annual Meeting. New York, NY.

  9. Kavowitz, A., Pisner, D., Crothers, R., Tegenkamp, K., Bickford, D., Nelson, C., Mackin, R.S., (2014). Association of Body Mass Index (BMI) and Depression Severity in Late Life Depression. Poster Presented at the American Psychiatric Association Annual Meeting. New York, NY.

  10. Kivowitz, A, Insel, P., Bickford, D., Hirt, M., Tosun, D., Yohannes, S., Mueller, S., Brewer, J., Truran-Sacrey, D., Aisen, P., Schuff, N., Weiner, M., Nelson, C., Mackin, R. S., ADNI (2013) Four Year Longitidinal Cognitive Decline Associated with Chronic Subsyndromal Symtpoms of Depression In Individuals with Mild Cognitive Impairment. Poster presented at the Alzheimer’s Research Symposium. Santa Barbara, CA.

  11. Hirt, M., Bickford, D., Kivowitz, A., Brewer, J., Elite-Marcandonatou, A., Nelson, C., Mackin, R. S. (2013). Association of Cortical Thickness to Cognitive Functioning in Late Life Depression. Poster presented at the annual meeting of the American Psychiatric Association. San Francisco, CA.

  12. Bickford, D., Hirt, M., Baez, L., Kivowitz, A., Nelson, J.C., & Mackin, R.S. (2013).  Impaired financial capacity in late life depression and its relationship to cognitive functioning and cortical thickness.  Poster presented at the annual meeting of the American Association of Geriatric Psychiatry, Los Angeles, CA.

  13. Fekri, S., Bistricky, S., Baker, M., Couture, L., Elite-Marcandonatou, A. , Nelson, J.C., & Mackin, R.S.  (2012).  The effect of anxiety on cognitive functioning and perception of cognitive difficulties in individuals with late life depression. Poster presented at the annual meeting of the American Association of Geriatric Psychiatry, Washington, DC.

  14. Mackin, R.S., Tosun, D., Nelson, J.C., Mueller, S., Insel, P., Schuff, N., Fekri, S., Truran-Sacray, D, Brewer, J., & Weiner, M.W. (2011). The association of cerebral hyperfusion on cognitive dysfunction in late life depression. Poster presented at the annual meeting of the International College of Geriatric Psychoneuropharmacology, Irvine, CA.

  15. Flach, K.G., Bistricky, S, Arean, P, & Mackin, R.S. (2011).  Expressive language impairments in older adults with late life depression. Poster presented at the Annual Conference of the American Society on Aging, San Francisco, CA.

  16. Flach, K.G. & Mackin, R.S. (2010).  Distributed cognitive impairments impact financial capacity in older depressed adults. Poster presented at the 2010 Bay Area Symposium on Clinical Research, San Francisco, CA.

  17. Mackin, R.S., Savla, G., Gillung, E, Ayalon, L., McKay, E., & Arean, P.A (2009). Suicidal ideation is associated with poorer performance on measures of executive functioning in individuals with late life depression. Poster presented at the 37th annual meeting of the International Neuropsychological Society, Atlanta.

  18. Mackin, R.S., Gillung, E, McKay, E., & Arean, P.A (2009). The impact of mild cognitive impairments on physical activities in the elderly. Poster presented at the 37th annual meeting of the International Neuropsychological Society, Atlanta.

  19. Mackin, R.S., Arean, P.A., Duffy, N., Gillung, E. (2008). Cognitive and psychiatric predictors of impaired financial capacity in older adults. Poster presented at the 36th annual meeting of the International Neuropsychological Society, Waikoloa.

  20. Mackin, R.S., Arean, P.A., Huh, T., Duffy, N., Gillung, E. (2008). Impact of cognitive impairment on cost of medical services among participants at a community mental health facility.  Poster presented at the 36th annual meeting of the International Neuropsychological Society, Waikoloa.

  21. Mackin, R.S., Arean, P.A., Duffy, N., Gillung, E. (2007). Incidence and documentation of mild cognitive impairment in community mental health center patients. Poster presented at the 20th annual meeting of the American Association for Geriatric Psychiatry, New Orleans.

  22. Mackin, R.S., Arean, P.A. (2006). Cognitive and psychiatric predictors of medical treatment adherence in primary care patients. Poster presented at the 19th annual meeting of the American Association for Geriatric Psychiatry, San Juan.

  23. Rodriguez, S., Arean, P.A., Shumway, M., Mackin, R.S. (2005). The effects of ethnicity on patient report of anxious and depressive symptoms. Poster presented at the UCSF Summer Research Institute, San Francisco.

  24. Mackin, R.S., Arean, P.A., Aldebot, S., Gillung, B.A. (2005). Cognitive and psychiatric predictors of medical treatment adherence among older adults in primary care. Poster presented at the annual meeting of American Association for Geriatric Psychiatry, San Diego.

Publications

  1. Mackin, R.S., Insel, P.S., Nelson, C., Tosun, D., Mattsson, N., Mueller, S.M., Sacuiu, S., Aisen, P.S., Schuff, N., Bickford, D., Crothers, R., Weiner, M.W., ADNI. [In-Press]. Cortical atrophy is associated with accelerated cognitive decline in mild cognitive impairment with subsyndromal depression. American Journal of Geriatric Psychiatry.
  2. Insel, P., Donohue, M., Mackin, S. R., Aisen, P., Hansson, O., Weiner, M., & Mattsson, N. (2016). Cognitive and functional changes associated with A <beta> pathology and the progression to mild cognitive impairment. Neurobiology of Aging. [“E-Pub Ahead of Print”].
  3. Insel PS, Mattsson N, Mackin RS, Scholl M, Nosheny R, Tosun-Turgut D, Donohue MC, Aisen PS, Jagust WJ, & Weiner MW. (2016). Alzheimer's Disease Neuroimaging Initiative Accelerating rates of cognitive decline and imaging biomarkers associated with beta-amyloid pathology, Neurology. 86 (20):1887-1896.
  4. Sacuiu, S., Insel, P., Mueller, SG, Tosun, D, Mattsson, N, Jack, CR, DeCarli, C, Petersen, R.R, Aisen, PS, Weiner, MW, & Mackin, RS for the Alzheimer's Disease Neuroimaging (2016).  Chronic depressive symptomatology in mild cognitive impairment is associated with frontal atrophy rate which hastens conversion to dementia, The American Journal of Geriatric Psychiatry, 24(2):126-135.
  5. Insel PS, Mattsson N, Mackin RS, Kornak J, Nosheny R, Tosun-Turgut D, Donohue MC, Aisen PS, Weiner MW; Alzheimer's Disease Neuroimaging Initiative (2015). Biomarkers and cognitive endpoints to optimize trials in Alzheimer's disease. Annals of  Clinical and Translational Neurology, 2(5):534-47.
  6. Mackin, RS, Insel, P, Zhang, J, Mohlenhoff, B, Galasko, D, Weiner, MW, & Mattson, N (2015). Cerebrospinal fluid a-synuclein and lewy body-like symptoms in normal controls, mild cognitive impairment, and Alzheimer’s disease. Journal of Alzheimer’s Disease, 43(3) 1007-16.
  7. Mackin, RS, Nelson, C, Delucchi, K, Raue, D, Satre, D, Alexopoulos, GS, & Areán, PA (2014). Association of Age of Depression Onset with Cognitive Functioning in   Individuals with Late Life Depression and Executive Dysfunction. American Journal of Geriatric Psychiatry, 22(12): 1633-4.
  8. Mackin, RS, Nelson, C, Delucchi, K, Raue, P, Byers, A, Barnes, D, Satre, D., Yaffe, K, Alexopoulos, GS, & Areán, PA (2014). Cognitive outcomes following psychotherapeutic interventions for major depression in older adults with executive dysfunction. American Journal of Geriatric Psychiatry, 22(12): 1496-503
  9. Mackin, RS, Insel, P, Tosun, D, Mueller, SG, Schuff, N, Truran-Sacrey, D, Raptentsetsang, S, Jack, CR, Aisen, PS, Petersen, RC, & Weiner, MW (2013). The effect of subsyndromal symptoms of depression and white matter lesions on disability for individuals with mild cognitive  impairment. American Journal of Geriatric Psychiatry, 21(9), 906-914.
  10. Mackin, RS, Tosun, D, Mueller, SG, Schuff, N., Lee, JY, Insel, P, Truran-Sacrey, D, Arean, PA, Nelson, JC, & Weiner, MW. (2013). Patterns of reduced cortical thickness  in late life depression and relationship to psychotherapeutic response. American Journal of Geriatric Psychiatry, 21(8), 794-802.
  11. Mackin, RS, Lessylong, J, and Yaffe, K (2012). Patterns of cognitive impairment in older veterans with post-traumatic stress disorder evaluated at a memory disorders clinic.  International Journal of Geriatric Psychiatry, 27: 637-642.
  12. Mackin, RS, Insel, P, Aisen, PS, Geda, YE, & Weiner, MW (2012). Longitudinal stability of subsyndromal symptoms of depression in individuals with Mild Cognitive Impairment: Relationship to conversion to dementia after three years. International Journal of Geriatric Psychiatry, 27(4), 355-363.
  13. Mackin, RS, Delucchi, K, Bennett, B & Arean, PA (2011). The effect of cognitive impairment on mental healthcare costs for older adults with severe psychiatric illness. American Journal of Geriatric Psychiatry, 2(19), 176-184.
  14. Mackin, RS, Ayalon, L., Feliciano, L., and Arean PA (2010). The sensitivity and specificity of the Mini Mental Status Exam and the Stroop Color Word Test in detecting cognitive impairment in older adults with severe mental illness. Journal of Geriatric Psychiatry and Neurology, 23(2), 94-99.
  15. Mackin, RS & Arean, PA (2009). Impaired financial capacity in late life depression is associated with  cognitive performance on measures of executive functioning and attention. Journal of International Neuropsychological Society, 15, 793-798.
  16. Mackin, RS & Arean, PA (2009). Incidence and documentation of cognitive impairment in older adults with severe mental illness. The American Journal of Geriatric Psychiatry, 17(1), 75-83.